South Carolina Highway Patrol responded to a fatal wreck on I-85 South near mm 28 Southbound in Anderson County.
Linda Ann Lusk, 48, of Stone Mountain, GA, was headed back to Lawrenceville, GA after making a delivery for Autozone in Taylors, SC.
Lusk made an improper lane change into the far right lane on I-85 South, striking a 18-wheeler and a box truck, troopers say.
Lusk was trapped inside the Autozone van and died at the scene.
The drivers of the 18-wheeler and the box truck were not hurt.