Three crashes, one involving a tractor trailer that struck a guardrail and went off of the road, and closed all lanes of I-85 southbound for a time at mile marker 17 in Anderson County around 7 pm Saturday.
Three other cars were involved in two additional wrecks. Two people were taken to AnMed Health Medical Center.
Traffic was backed up to near Exit 21.
The Anderson County Sheriff’s Office and the Highway Patrol says I-85 opened back up just after 9 pm Saturday.